Information about MELSMON Injections

This injection is used to improve the following diseases or symptoms.

To improve various symptoms of menopausal disorder, such as hot flushes, feeling cold, insomnia, irritation, headaches, fatigue, stiff neck and shoulders, or back pain). It is also used to treat women who have poor lactation after childbirth.

This injection may cause the following adverse reactions.

It may cause pain or redness at the injection site, chills, fevers, rashes, etc. If you experience such symptoms, please inform your doctor.

Safety concerning viruses or bacteria

The manufacturer takes measures to prevent infection by viruses and bacteria as follows:
The manufacturer performs viral tests on each placenta and confirms that it is negative for HBV, HCV, and HIV before using it as a safe raw material. In addition, the manufacturer performs steam sterilization under pressure at 121oC (250oF) for 30 minutes during the final stage of manufacturing.
No viral infections have been reported that might be caused by this drug.

Safety concerning variant Creutzfeldt-Jakob disease (vCJD)*

Mad cow disease was observed mainly in the United Kingdom from the 1980s until approximately 2004. Consequently, variant Creutzfeldt-Jakob disease (vCJD), which was thought to be related to the intake of beef derived from a sick cow, was reported.

Melsmon injections do not use the placentas of women who stayed in affected regions during the epidemic of mad cow disease. In addition, the manufacturer heat-treats the product using hydrochloric acid during the manufacturing procedure, resulting in the degradation of any hormones and proteins present.
*Creutzfeldt-Jakob disease (CJD) is a very rare disease in which abnormal prion protein accumulates in the brain and causes brain symptoms, such as progressive dementia or motor dysfunction. CJD that is thought to be caused by the consumption of mad cow disease infected beef is termed variant CJD.

Restrictions of donation of blood and organs

Globally, there have been reports of infections that are suspected to have been caused by blood transfusions or
organ transplants, but there have been no reports of vCJD thought to have been a result of a Melsmon injection. However, the theoretical risk of the transmission of vCJD and other diseases cannot completely be excluded. Therefore, those who have used drugs derived from human placentas, including Melsmon injections, are not allowed to donate blood. These people are also requested to refrain from organ donation in principle.
For organ donation, however, donation is possible if a transplant applicant receives an appropriate explanation from a transplant surgeon and reveals her/his intentions to accept the donation.